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DOSE-DEPENDENT CLOZAPINE-INDUCED EOSINOPHILIA: A CASE REPORT OF AN UNUSUAL ADVERSE DRUG REACTION
Address for correspondence: Dr. Sharmila Sarkar, Department of Psychiatry, Calcutta National Medical College and Hospital (2nd Campus), Calcutta Pavlov Hospital, 18, Gobra Road, Kolkata - 700 046, West Bengal, India. E-mail: dr_ghoshs@yahoo.co.in
Abstract
Clozapine is the only antipsychotic which is effective in ‘Treatment-Resistant Schizophrenia’. However, it is associated with many side effects. Among those, eosinophilia is considered to be a non-dose dependent adverse drug reaction. We present here a case of a dose-dependent severe eosinophilia following clozapine therapy. In spite of extensive search of PubMed and Medline database we could not find any previous report of clozapine induced dose-dependent eosinophilia in the English language literature.